"Tapentadol" A Novel Anagegic

– Tapentadol is a new analgesic drug with a dual mode of action, hence has efficacy in a broad spectrum of acute and chronic pain models and possibly an improved tolerability profile. It combines moderate mu–opioid agonist activity with NE reuptake inhibition in a single, nonracemic molecule. No metabolic activation of tapentadol is necessary for analgesia, and it has no active metabolites. Further RCTs are needed to establish its routine use in postoperative patients.